Esomeprazole is a proton pump inhibitor it has a dose dependent suppression of gastric acid secretion; without anticholinergic or H2 blocking action. It is a powerful inhibitor of gastric acid: can totally abolish HCl secretion, both resting as well as that stimulated by food or any of the secretagogues, without much effect on pepsin, intrinsic factor, juice volume and gastric motility.
Domperidone is a prokinetic drug, it blocks the D2 receptors in the upper GIT and hastens gastric emptying and prevents emesis and reflux.
Effective control of excessive acid problems in gastroesophageal reflux disease
Has greater bioavailability (89%) compared to pantoprazole (77%)